Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis
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چکیده
منابع مشابه
Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.
In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion ...
متن کاملBrief Communications Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis
In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain– behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion...
متن کاملThe bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear.
While learning to fear stimuli that predict danger promotes survival, the inability to inhibit fear to inappropriate cues leads to a pernicious cycle of avoidance behaviors. Previous studies have revealed large inter-individual variations in fear responding with clinically anxious humans exhibiting a tendency to generalize learned fear to safe stimuli or situations. To shed light on the origin ...
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s | 3 reinstatement was accompanied by reduction of synaptic input in the IL. Then we hypothesized that prefrontal dopamine plays a key role in reinstatement and tested this idea. A reminder shock induced c-Fos expression in the IL-projecting dopaminergic neurons in the ventral tegmental area. Blocking of IL dopamine D1 receptor signaling prevented reduction of synaptic input, CeM c-Fos express...
متن کاملThe effects of lesions of the bed nucleus of the stria terminalis on sodium appetite.
Lesions of the bed nucleus of the stria terminalis result in decrements in sodium ingestion. Specifically, sodium ingestion that is aroused by mineralocorticoids, in addition to sodium depletion, was reduced in rats with large lesions of the bed nucleus of the stria terminalis. Need-free salt ingestion was also reduced. These results suggest that the bed nucleus of the stria terminalis may be i...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2010
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5952-09.2010